![]() ![]() Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides. ![]() Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats. Pourkhalili N, Hosseini A, Nili-Ahmadabadi A, Hassani S, Pakzad M, Baeeri M, et al. Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. 2016 5:15.ĭas M, Patil S, Bhargava N, Kang J-F, Riedel LM, Seal S, et al. Antioxidant cerium oxide nanoparticles in biology and medicine. Nelson B, Johnson M, Walker M, Riley K, Sims C. The role of cerium redox state in the SOD mimetic activity of nanoceria. Heckert EG, Karakoti AS, Seal S, Self WT. Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Cerium oxide nanoparticles: applications and prospects in nanomedicine. 2005 142:276–88.ĭas S, Dowding JM, Klump KE, McGinnis JF, Self W, Seal S. The influence of a cerium additive on ultrafine diesel particle emissions and kinetics of oxidation. Structure-sensitive properties and biomedical applications of nanodispersed cerium dioxide. Pharmacological properties of cerium compounds. We envision that PEGylated rod-shaped CNPs synthesized in this study have the potential to be biocompatible nanoparticles that can combat oxidative stress-related diseases. The antioxidant effects of CNPs were maintained in PEGylated CNPs. Importantly, PEGylation significantly reduced the amount of proteins adsorbed onto the CNPs. PEGylation of CNPs did not affect shape, cerium oxidation state, and cytocompatibility. Rod-shaped CNPs demonstrated greater reactive oxygen species scavenging ability compared to cube-shaped CNPs. The chemical conjugation of PEG onto the CNP surface was confirmed by a series of physico-chemical characterizations ( 1H-NMR, FTIR, and surface zeta potential). In this study, we have demonstrated a simple method to functionalize shape-specific CNPs (i.e., rod- and cube-shaped) with polyethylene glycol (PEG) and studied the effect of PEGylation on the physico-chemical properties, antioxidant activity, and biocompatibility of rod- and cube-shaped CNPs. Due to the easily reversible oxidation states of cerium (Ce 3+ and Ce 4+) at the nanoscale, CNPs scavenge excessive reactive oxygen and nitrogen species in a self-regenerative manner. ![]() Cerium oxide nanoparticles (CNPs) represent a promising class of antioxidant nanoparticles with potential therapeutic value. ![]()
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